In the world of dermatological science, efficacy is often limited by a single, immutable law of physics: the 500 Dalton Rule. First defined in dermatological pharmacology, this rule posits that for any molecule to freely penetrate the skin barrier (the stratum corneum) and affect the deeper dermal layers, it must have a molecular weight of under 500 Daltons. This microscopic barrier is precisely why fermentation has emerged as the critical technology for modern skincare—it is the only biological process capable of breaking down complex actives to fit through this gate.
To put this in perspective, many of the most popular ingredients in luxury skincare—including standard collagen, hyaluronic acid, and complex botanical extracts—far exceed this limit. They are physically too large to enter the skin. Instead, they sit on the surface, providing temporary hydration but failing to initiate the structural repair required for true anti-aging.
This biological barrier is the primary catalyst behind the establishment of the Dr.TWL Asian Bio-Dermatology Institute. Headquartered in Singapore with a new, dedicated research division in the botanical biotechnology epicenter of China, the Institute was founded to engineer a way around this physical limitation. Rather than relying on higher concentrations of surface-level ingredients, the Institute focuses on Enzymatic Hydrolysis—a bio-engineering process that fundamentally alters the molecular structure of skincare formulations.
Dr.TWL’s Fermentation Engine
Through the Institute’s proprietary Fermentation Engine, raw medicinal botanicals such as Mugwort (Artemisia) and Rice (Oryza Sativa) are subjected to controlled enzymatic activity. This process acts as a pair of molecular scissors, cleaving the long-chain bonds of these complex ingredients. The result is the reduction of active compounds into micro-molecular weights that are small enough to bypass the 500 Dalton Rule.
This technology is the backbone of the newly announced Fermentation Facelift ™. By ensuring that active ingredients are pre-digested into their most bio-available form, this protocol allows for deep dermal delivery without the need for invasive needles or mechanical devices.
The Institute’s work represents a paradigm shift from the brand’s original Founders Formula to the new Bibang Formula ™ (Secret Prescription). It is a transition from simple extraction to Yakzen (Medicinal Nutrition)—a system where ancient herbal wisdom is validated and optimized by the precision of modern biotechnology.
Read the official announcement of the Dr.TWL Asian Bio-Dermatology Institute launch